ENGLAND: M Brown (Harlequins); J Nowell (Exeter), J Joseph (Bath), O Farrell (Saracens), E Daly (Wasps); G Ford (Bath), B Youngs (Leicester); J Marler (Harlequins), D Hartley (Northampton, capt), D Cole (Leicester), J Launchbury (Wasps), C Lawes (Northampton), M Itoje (Saracens), J Haskell (Wasps), N Hughes (Wasps).
Replacements: 16 Jamie George, 17 Mako Vunipola, 18 Kyle Sinckler, 19 Tom Wood, 20 Billy Vunipola, 21 Danny Care, 22 Ben Te'o, 23 Anthony Watson.
Scotland: Hogg (Glasgow); Seymour (Glasgow), Jones (Stormers), Dunbar (Glasgow), Visser (Harlequins), Russell (Glasgow), Price (Glasgow); Reid (Glasgow), Brown (Glasgow), Fagerson (Glasgow), R Gray (Toulouse), J Gray (Glasgow), Barclay (Scarlets, capt), Watson (Edinburgh), Wilson (Glasgow).
Replacements: Ford, Dell, Berghan, Swinson, Du Preez, Pyrgos, Weir, Bennett. Scotland can be backed at 10/11 with an 11 point handicap, while Eddie Jones' side are available at 6/5 to win by 13 points of more.
The indications were that Jones might pick Vunipola in place of Nathan Hughes after pictures emerged of Jones's intended XV on a whiteboard during a training session at England's Bagshot base on Tuesday.
"The odds are that England will move on to 18 wins in a row and the visitors' long run of defeats at Twickenham will continue".
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England host Scotland on Saturday in what is expect to be the most competitive Calcutta Cup clash in recent memory as the Scots have looked a dramatically improved outfit in the championship this year, but while Italy surprised England and caught them off guard with their tactics in the ruck, Jones is not expecting any sort of unexpected difficulties this time out. "He just ran into someone at training - as simple as that. He'll be all right, possibly". That is nearly certainly Jones's deliberate objective: to jolt his players out of any complacency and encourage them to assume more responsibility rather than hiding behind their head coach's extensive collection of bon mots. We're happy with the way he's going.
Scotland head coach Vern Cotter: "The challenge is for us to combine the best parts of our performances so far in this campaign in to one excellent performance at Twickenham this Saturday".
Scotland have not beaten England in their past eight attempts.
England is attempting to equal the Tier 1 world record for consecutive Test victories, now 18 matches and held by New Zealand.
England was the only remaining unbeaten team in the Six Nations but has won ugly against France, Wales, and Italy.
Should they prevail, it will be their first Triple Crown since 1990. Sir Ian McGeechan's side went on to win the Grand Slam that year.