Russian defence ministry spokesman Maj Gen Igor Konashenkov said the strike destroyed six Syrian air force MiG-23 fighter jets which were undergoing repairs, but did not damage other warplanes at the base.
Rebel factions in Syria have welcomed the USA missile strike on an air base in Syria's central province of Homs, a media report said on Friday.
The Syrian Observatory for Human Rights said the aircraft "took off from inside the Shayrat base, which is partially back in service, and struck targets near Palmyra". Damascus has strongly denied carrying out the attack and says it does not use chemical weapons.
No matter how extensive the damage at Shayrat, Mr Assad has other options, Mr Hamade said.
But Syria and its Russian backers have many air bases and lots of military infrastructure in the country.
United States officials said Russia's military in Syria had been informed of the strike beforehand in order to avoid casualties that could prompt a broader crisis.
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The missiles struck their targets, which also included Syrian aircraft and fuel stations, at 4.40am local time on Friday. US Secretary of State Rex Tillerson said Washington had "no doubt" it was the Syrian leadership behind the attack.
Syrian warplanes took off from an airbase just hours after it was hit by United States cruise missiles on Friday, and carried out strikes on rebel-held areas in the eastern Homs countryside, the Syrian Observatory for Human Rights said.
The United States launched the missile strikes on Friday in response to a chemical attack that killed 90 people including 30 children.
American officials described the attack - the first direct US assault on the government of President Bashar al-Assad in six years of civil war - as a one-off that would not lead to wider escalation.
"The strikes have been carried out against Syrian government's troops in violation of the global law", Lavrov said at the 25th Assembly of Russia's Council on Defense and Foreign Policy (CDFP).
Al-Talawy said that after the bombing dozens of ambulances rushed to the area to evacuate the wounded adding that people living nearby saw balls of fire that lit through the sky when the missiles hit the base.