Mattek-Sands needed morphine and oxygen as she went into shock on Court 17 after appearing to dislocate her right knee-cap in a horror fall.
Cirstea climbed over the net to check on her opponent and was evidently upset by what she saw. I panicked a little bit as well and called for help but no one was coming and I tried to comfort her as much as I could but you could feel the pain.
It's an unfortunate turn for Mattek-Sands, who was looking to complete a calendar-year Grand Slam in doubles after capturing the Australian Open and the French Open titles already in 2017.
Unfortunately, Bethanie blew out her knee during her match on Thursday and was forced to withdraw.
In obvious distress, Mattek-Sands screamed out "Help me" as she lay on the turf in front of horrified spectators. "These painkillers are not working", she was heard to say before she was taken off the court, according to The Sun.
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Safarova was later seen arriving at the court in tears.
She was eventually attended to by medical personnel.
Maria Sharapova said the surface on Court Two where she lost to Michelle Larcher de Brito was "dangerous" after she fell a number of times. Her knee was in a very weird position.
Speaking for the first time about the incident, Cirstea said: "I'm not a doctor, I'm not a specialist. I felt useless. All she kept saying was 'Sorana, help me, help me".
The Woman's Tennis Association said Mattek-Sands had suffered an acute knee injury and had been taken straight to hospital.