Alongside a starting XI that can rival any top side on the planet, there are high expectations of them this season to break the duck and win the title for the first time in nearly 6 decades.
Spurs travel to St James' Park to face the newly promoted side hoping to avenge a 5-1 defeat on Tyneside when the sides last met at the end of the 2015-16 campaign.
However, he has been given the nod to start against his former club, on the right-hand side of a midfield triumvirate alongside Christian Eriksen and Dele Alli. The tackle on the later was particularly rash, as Harry Kane was duly booked for a conventional, poorly timed, striker's challenge.
With 20 minutes left, Ben Davies was found by Eriksen with the Welshman scoring the second goal of the game.
Jacob Murphy and Mikel Merino are named among the substitutes on the bench, but could make their debuts for Newcastle.
Roy's aunt: Give Michelle Carter 20 years
Reportedly, the prosecutor told the court that, " Only her actions killed Conrad Roy and she tried to end to his life to improve her life".
Pochettino said: "He was calm - that's important".
Sissoko was taken off after 57 minutes, a tactical swap for Son Heung-min, and within three minutes Spurs took the lead.
After a first half in which he had been the visitors' most threatening attacker, drifting infield from the left flank to take up unsafe positions between the lines, the Dane delivered a sumptuous cross to allow Alli to open the scoring just after the hour-mark.
Pochettino, however, admitted his side had found it hard to break Rafael Benitez's men up until that point: "We knew how they play, so narrow and deep". "We'll try to sign a few players more, we're trying hard to bring some new energy". He eclipsed Pogba a year ago.
Kane was denied his 100th goal for Spurs by the foot of the post in the 90th minute.