Karius' first outing saw him concede twice as Sevilla scored a late equaliser at Anfield a fortnight ago, although neither goal was his fault.
Nemanja Matic, who also suffered an injury against Southampton, flew out with the rest of the squad along with defender Eric Bailly, who could make his Champions League debut for the club.
"He will play tomorrow and we will see, but Simon is the No.1 and that's the situation", Klopp added.
A move to Barcelona would have seen Coutinho comfortably double his weekly wages
His patience nearly snapped when he was asked whether he was in love with any of his players, a reference to Tottenham coach Mauricio Pochettino saying he loved striker Harry Kane.
Translation problems, technical difficulties and some obscure questions from both local and global media frustrated the Liverpool manager, who declared the final question of the session a "waste of time". We have a lot of good players already. "Defence, how I understand it, is a team-work thing so that's what we speak about and talk about", he said. "We sometimes take a few risks in defence". Three goals or whatever, Actually I love Harry too.
They are virtually unplayable when they flick on the jets going forward and Klopp now has the luxury of unleashing his most potent quartet of Sadio Mane, Philippe Coutinho, Roberto Firmino and Mo Salah all at the same time in the Russian capital. It is not important for Russian Federation.
As Jürgen Klopp addressed the media ahead of Liverpool's game with Spartak Moscow he spoke about a number of topics.
There is a big temptation then to follow the trend and make an investment on the goals to flow and it is just a question of how courageous you feel.
1 dead, 7 injured after gunman opens fire at Tennessee church
He then went inside the rear of the church and opened fire, setting off multiple rounds, wounding six people. A woman who lives near the church told WKRN-TV that shooting victims showed up at her door.